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Overcoming Antibiotic Resistance Through the Inhibition of Aminoglycoside Phosphotransferases (APH).

Overcoming Antibiotic Resistance Through the Inhibition of Aminoglycoside Phosphotransferases (APH).
通过抑制氨基糖苷磷酸转移酶 (APH) 克服抗生素耐药性。
批准号：
269774
负责人：
Capretta Alfredo A
金额：
$24.64万
依托单位：
McMaster University
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-10-01 至 2015-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=269774&lang=en
关键词：
Aminoglycoside Phosphotransferases Antibiotic Resistance Enzymes (5404) Human Health (1101) Medical And Health Sciences (1211) Medicinal Chemistry Organic Syntheses (3703) Rational Based Drug Design Structural Biology X-Ray Crystallography

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Multidrug resistant microbes have become one of the top global health challenges and place a massive burden on the Canadian health care system. One approach to overcome this problem involves inhibiting the enzymes responsible for conferring resistance to
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