Itch PRD domain and specificity of function

Itch PRD结构域和功能特异性

• 批准号: 288238-2009
• 负责人: Angers, Annie
• 金额: $ 2.33万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525748
• 关键词: Itch; PRD; domain; specificity; function

A multicellular organism can be viewed as a community of individual cells that live in a very organized society. This society relies on an intricate communication network that control individual cell fate, survival, and proliferation to ensure the well being of the global organism. Each cell at its turn possesses a very complex molecular network to control the different aspects of its function and development. If, globally, all cells are comparable, the exact network composition of each individual cell must be adjusted to allow each cell specific function and control its growth in the limits of its particular tissue. We are studying ubiquitin ligases, a particular class of proteins that are a very important part of the regulating machinery responsible for fine tuning and adjustment of specific parts of the cell molecular network. By studying this class of enzyme, how they are controlled, and how in turn they control other proteins, we hope to gain a better understanding of cellular physiology, and how it is properly maintained in health, or altered in disease.

多细胞生物可以被看作是生活在一个非常有组织的社会中的单个细胞的社区。这个社会依赖于一个复杂的通信网络，控制单个细胞的命运，生存和增殖，以确保全球有机体的健康。每个细胞都有一个非常复杂的分子网络来控制其功能和发育的不同方面。如果所有细胞都是可比较的，那么必须调整每个细胞的确切网络组成，以允许每个细胞发挥特定功能，并在其特定组织的限制下控制其生长。我们正在研究泛素连接酶，这是一类特殊的蛋白质，是负责细胞分子网络特定部分的微调和调整的调节机制的非常重要的组成部分。通过研究这类酶，它们是如何被控制的，以及它们又是如何控制其他蛋白质的，我们希望能更好地了解细胞生理学，以及它是如何在健康状态下得到适当的维持，或在疾病中得到改变的。