Technical development of sodium magnetic resonance imaging of the human knee

人体膝关节钠磁共振成像技术进展

• 批准号: 293226-2009
• 负责人: Beaulieu, Christian
• 金额: $ 3.5万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525834
• 关键词: Technical; development; sodium; magnetic; resonance

Engineering advances of hardware and software over the last 25 years have made magnetic resonance imaging (MRI) indispensable for the diagnosis and improved understanding of many human diseases and disorders. Routine clinical MRI measures signal from the hydrogen nucleus (i.e. proton, 1H) of water and it is unique differences in the water properties of tissue that yields image contrast. However, with the appropriate engineering, MRI can acquire signal from a different nucleus, namely the naturally abundant sodium (23Na) ion within the body. Sodium is linked directly to proper cell function, and may provide evidence of tissue injury despite normal appearance on conventional MRI. Sodium MRI is inherently very challenging because of low sensitivity due to sodium's low concentration in tissue and complicated physics responses. Therefore, sodium MRI is a non-standard imaging technique not available on most clinical 1.5T (i.e. strength of the magnetic field) MRI scanners because of the lack of appropriate electronics and specialized imaging pulse sequences. Imaging is more sensitive if the MRI scanner has a very strong magnetic field. This proposal will take advantage of a very strong "triple strength" MRI scanner (4.7T) located at the University of Alberta.

在过去的25年里，硬件和软件的工程进步使得磁共振成像（MRI）对于诊断和提高对许多人类疾病和障碍的理解不可或缺。常规临床MRI测量来自水的氢核（即质子，1H）的信号，并且产生图像对比度的是组织的水性质的独特差异。然而，通过适当的工程设计，MRI可以从不同的细胞核获取信号，即体内天然丰富的钠（23 Na）离子。钠与适当的细胞功能直接相关，尽管在常规MRI上表现正常，但可能提供组织损伤的证据。由于钠在组织中的低浓度和复杂的物理响应导致的低灵敏度，钠MRI本质上非常具有挑战性。因此，钠MRI是一种非标准成像技术，由于缺乏适当的电子设备和专门的成像脉冲序列，大多数临床1.5T（即磁场强度）MRI扫描仪无法使用。如果MRI扫描仪具有非常强的磁场，则成像更敏感。该提案将利用位于阿尔伯塔大学的非常强大的“三倍强度”MRI扫描仪（4.7 T）。