Advancing intact proteome separation for top-down and bottom-up mass spectrometry

推进自上而下和自下而上质谱分析的完整蛋白质组分离

• 批准号: 311803-2010
• 负责人: Doucette, Alan
• 金额: $ 2.91万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=526265
• 关键词: Advancing; intact; proteome; separation; top

Imagine what it would be like to obtain your own medical history from a single drop of blood. By analyzing protein molecules (responsible for carrying out practically all biochemical functions), a physician could diagnose the early onset of disease, and perhaps even prescribe treatments to prevent the illness, even before you get sick! This is the dream of PROTEOMICS, an emerging science that utilizes advanced analytical techniques to characterize extremely complex biological mixtures (several thousand proteins detected in a single experiment).

想象一下，从一滴血中获得你自己的病史会是什么样子。通过分析蛋白质分子（负责执行几乎所有的生化功能），医生甚至可以在你生病之前就诊断出疾病的早期发作，甚至开出预防疾病的治疗方案！这是蛋白质组学的梦想，这是一门新兴的科学，利用先进的分析技术来表征极其复杂的生物混合物（在一次实验中检测到数千种蛋白质）。