The genetics of altitude acclimatisation in humans

人类海拔适应的遗传学

• 批准号: 312250-2011
• 负责人: Rupert, Jim
• 金额: $ 1.75万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=526453
• 关键词: genetics; altitude; acclimatisation; humans

The capacity to acclimatise to hypoxia varies at both the individual and the population level. One of my central research goals is to understand the extent to which, and by what mechanisms, genetic background contributes to this variation. The model we use is acute mountain sickness (AMS), which is a manifestation of inadequate or delayed altitude acclimatisation. Our objectives for the next five years are fourfold:

适应缺氧的能力在个体和群体水平上都不同。我的中心研究目标之一是了解遗传背景在多大程度上以及通过何种机制促成这种变异。我们使用的模型是急性高山病（AMS），这是高原适应不足或延迟的表现。 我们未来五年的目标有四个：