Modelling intermediate filament networks

中间丝网络建模

• 批准号: 327614-2013
• 负责人: Portet, Stephanie
• 金额: $ 2.19万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527033
• 关键词: Modelling; intermediate; filament; networks

The intermediate filament (IF) network is part of the cytoskeleton, an intracellular structure made of proteins polymerized in filaments forming networks in the cytoplasm. The IF network is mainly involved in the stabilization and mechanical resilience of the cell, cell migration and signal transduction. The organization of cytoskeletal networks is the main determinant of their mechanical properties and so their functions in the cell. Defects in the assembly or the transport of cytoskeletal proteins, resulting in network misorganizations, are linked to the pathogenesis of many diseases.

中间丝（IF）网络是细胞骨架的一部分，细胞骨架是一种由蛋白质聚合成丝在细胞质中形成网络组成的细胞内结构。IF网络主要参与细胞的稳定和机械弹性、细胞迁移和信号转导。细胞骨架网络的组织是其机械性质的主要决定因素，因此它们在细胞中的功能。细胞骨架蛋白的组装或运输缺陷导致网络错误组织，与许多疾病的发病机制有关。