Optimal adaptive treatment strategies: Finding practical solutions to inferential challenges

最佳适应性治疗策略：寻找推理挑战的实用解决方案

• 批准号: 331271-2009
• 负责人: Moodie, Erica
• 金额: $ 1.17万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527163
• 关键词: Optimal; adaptive; treatment; strategies; Finding

Dynamic (or adaptive) treatment regimes are strategies in which treatment decisions are based on patient-specific characteristics that may vary over time, characteristics that may be demographic such as age or sex but may also be clinical, for example response to treatment in the past. It is very difficult to learn about the best adaptive treatment strategies, and so this area of research contains many open problems. In particular, it can be difficult to decide which patient characteristics are important to use to tailor, or individualize, treatment.

动态(或适应性)治疗制度是一种策略，其中的治疗决定基于患者特定的特征，这些特征可能会随着时间的推移而变化，这些特征可能是年龄或性别等人口统计学特征，但也可能是临床特征，例如过去对治疗的反应。要了解最好的适应性治疗策略是非常困难的，因此这一领域的研究包含了许多开放的问题。特别是，很难决定哪些患者的特征是重要的，以量身定做或个性化治疗。