Androgen regulation of intestinal lipid metabolism, and the impact of dietary lipids

雄激素对肠道脂质代谢的调节以及膳食脂质的影响

• 批准号: 341320-2013
• 负责人: Vine, Donna
• 金额: $ 1.82万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527265
• 关键词: Androgen; regulation; intestinal; lipid; metabolism

The intestine is an important organ in absorption, secretion and metabolism of nutrients, in particular dietary fats. How the body regulates intestinal lipid absorption-secretion and metabolism throughout the lifecycle is largely unknown. Emerging evidence suggests hormones, such as testosterone, may have a direct effect on regulating lipid synthesis in tissues in the body which can change blood lipids and impact health status. The aim of this research program is to determine the role of testosterone in regulating intestinal lipid metabolism by examining lipid absorption and transport processes using animal models. The findings of this work will provide new data in this area to help us understand the higher regulation of the intestine by hormones, such as testosterone, and can be further translated to human health in different stages of the lifecycle in which testosterone levels change and to conditions where testosterone levels in the body are too high or too low. In addition this research will investigate how dietary fats, in particular different polyunsaturated fatty acids including trans fats and n-3 fats, modulate testosterone metabolism in the body and how this impacts intestinal lipid metabolism. The outcomes of this research will help us to understand how different dietary fats can be used to modulate intestinal and testosterone metabolism in conditions where these processes are aberrant and in normal physiological stages of life.

肠道是营养物质，特别是膳食脂肪吸收、分泌和代谢的重要器官。在整个生命周期中，人体如何调节肠道脂质吸收分泌和代谢在很大程度上是未知的。新出现的证据表明，激素，如睾酮，可能对调节体内组织中的脂质合成有直接影响，这可能会改变血脂并影响健康状况。本研究计划的目的是通过使用动物模型检查脂质吸收和转运过程来确定睾酮在调节肠道脂质代谢中的作用。这项工作的发现将在这一领域提供新的数据，以帮助我们了解激素（如睾酮）对肠道的更高调节，并可以进一步转化为睾酮水平变化的生命周期不同阶段的人类健康以及体内睾酮水平过高或过低的条件。此外，这项研究将研究膳食脂肪，特别是不同的多不饱和脂肪酸，包括反式脂肪和n-3脂肪，如何调节体内的睾酮代谢，以及这如何影响肠道脂质代谢。这项研究的结果将帮助我们了解不同的膳食脂肪如何在这些过程异常和正常生理阶段的情况下用于调节肠道和睾酮代谢。