The relationship between intestinal lipid transport processes, insulin metabolism, and modulation by dietary lipids

肠道如何吸收和运输膳食脂肪是我们需要更好地了解所涉及的基本生理过程的主要领域。新出现的证据表明，肠道对全身胆固醇和甘油三酯代谢有显着贡献，但仍然缺乏关于肠道脂质吸收的调节以及膳食脂质通过肠道脂蛋白（乳糜微粒）转运到循环的知识。我们知道很多关于肝脏和它如何处理脂质，但我们对肠道如何调节脂质代谢的知识有限。我和其他人已经认识到饮食中的脂质含量可以改变乳糜微粒的肠道吸收和代谢。最近的证据表明，特定的肠道转运蛋白参与脂质吸收和肠道乳糜微粒的产生，这些过程可能与胰岛素代谢有内在联系。我的研究计划的主要目标是建立肠道脂质吸收，乳糜微粒产生和胰岛素状态之间的生理关系，以及膳食脂质在调节这些过程中可能发挥的作用。科学的策略是使用一种综合的方法与互补的技术，这是独特的，我的实验室，以调查'吸收分泌'轴的脂质代谢在肠道。据设想，这项研究计划将提供关于肠道如何处理膳食脂肪的机制见解，以及它如何适应或调节不同代谢和饮食条件下的肠道脂质转运过程。

How the intestine absorbs and transports dietary fats is major area where we need greater understanding of the basic physiological processes involved. Emerging evidence suggests the intestine contributes significantly to whole body cholesterol and triglyceride metabolism, yet there remains a lack of knowledge regarding the regulation of intestinal lipid absorption, and transport of dietary lipids to the circulation via intestinal lipoproteins (chylomicrons). We know a lot about the liver and how it handles lipids, but we have limited knowledge about how the intestine regulates lipid metabolism. I and others have contributed to the understanding that dietary lipid content can alter intestinal absorption and metabolism of chylomicrons. Recent evidence suggests that specific intestinal transporters are involved in lipid absorption and production of intestinal chylomicrons, and these processes may be intrinsically linked with insulin metabolism. The principle objective of my research program is to establish the physiological relationship between intestinal lipid absorption, chylomicron production, and insulin status, and the role dietary lipids may play in modulating these processes. The scientific strategy is to use an integrated approach with complimentary techniques which are unique to my laboratory to investigate the 'absorption to secretion' axis of lipid metabolism in the intestine. It is envisioned that this research program will provide mechanistic insights into how the intestine processes dietary fat, and how it adapts or modulates intestinal lipid transport processes in different metabolic and dietary conditions.