The relationship between intestinal lipid transport processes, insulin metabolism, and modulation by dietary lipids

肠道如何吸收和运输膳食脂肪是我们需要更多地了解涉及的基本生理过程的主要领域。新出现的证据表明，肠道对全身胆固醇和甘油三酯代谢有重要贡献，但对肠道脂肪吸收的调节，以及通过肠道脂蛋白(乳糜粒)将膳食脂肪输送到循环中的知识仍然缺乏。我们知道很多关于肝脏及其如何处理脂质的知识，但我们对肠道如何调节脂肪代谢的了解有限。我和其他人帮助理解了饮食中的脂肪含量可以改变乳糜粒的肠道吸收和代谢。最近的证据表明，特定的肠道转运体参与了肠道乳糜粒的脂肪吸收和产生，这些过程可能与胰岛素代谢有内在联系。我的研究计划的主要目标是建立肠道脂肪吸收、乳糜管产生和胰岛素状态之间的生理关系，以及饮食脂质在调节这些过程中可能扮演的角色。科学的策略是使用一种综合的方法和互补的技术，这些技术是我的实验室独有的，以研究肠道中脂肪代谢的“吸收到分泌”轴。据设想，这项研究计划将提供机械性的见解，了解肠道如何处理膳食脂肪，以及它如何适应或调节不同代谢和饮食条件下的肠道脂肪运输过程。

How the intestine absorbs and transports dietary fats is major area where we need greater understanding of the basic physiological processes involved. Emerging evidence suggests the intestine contributes significantly to whole body cholesterol and triglyceride metabolism, yet there remains a lack of knowledge regarding the regulation of intestinal lipid absorption, and transport of dietary lipids to the circulation via intestinal lipoproteins (chylomicrons). We know a lot about the liver and how it handles lipids, but we have limited knowledge about how the intestine regulates lipid metabolism. I and others have contributed to the understanding that dietary lipid content can alter intestinal absorption and metabolism of chylomicrons. Recent evidence suggests that specific intestinal transporters are involved in lipid absorption and production of intestinal chylomicrons, and these processes may be intrinsically linked with insulin metabolism. The principle objective of my research program is to establish the physiological relationship between intestinal lipid absorption, chylomicron production, and insulin status, and the role dietary lipids may play in modulating these processes. The scientific strategy is to use an integrated approach with complimentary techniques which are unique to my laboratory to investigate the 'absorption to secretion' axis of lipid metabolism in the intestine. It is envisioned that this research program will provide mechanistic insights into how the intestine processes dietary fat, and how it adapts or modulates intestinal lipid transport processes in different metabolic and dietary conditions.