Discovering novel molecular genetic mechanisms that integrate morphogenesis and cell fate determination during vertebrate embryonic development

发现脊椎动物胚胎发育过程中整合形态发生和细胞命运决定的新型分子遗传机制

• 批准号: 341568-2012
• 负责人: Ciruna, Brian
• 金额: $ 2.04万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527365
• 关键词: Discovering; novel; molecular; genetic; mechanisms

During vertebrate embryogenesis, an unassuming ball of cells rapidly proliferates, grows, and is actively re-modeled into a recognizable 'adult' body plan. This remarkable transformation involves countless changes in cell shape, pattern and movement, which ultimately assemble complex structures like the cranioskeleton (jaws and skull). Slight changes to any of these events can dramatically alter normal form.

在脊椎动物胚胎发生过程中，一个不起眼的细胞球迅速增殖、生长，并积极地重新塑造成可识别的“成人”身体结构。这种显着的转变涉及细胞形状、模式和运动的无数变化，最终组装成颅骨（颌骨和头骨）等复杂结构。这些事件中任何一个的轻微改变都会极大地改变正常的形态。