BIOMECHANICAL MODULATORS OF CARTILAGE AND BONE IN THE KNEE IN VIVO

关节软骨是一种特殊的，坚硬但灵活的组织衬里骨关节内，如膝盖。 该组织负责在身体活动期间沿沿着膝关节表面均匀分布巨大的机械负荷。 预期膝关节软骨在许多年的生命中管理这些机械负荷而不遭受损伤。 然而，机械负荷显然会导致软骨以及下面的骨结构破裂，导致关节炎。 很少有研究探索这些力学在降解或保护人类膝盖中的关节软骨和底层骨骼方面的复杂性。 本研究项目的目的是研究人类膝关节内关节软骨和底层骨对短期和长期机械载荷的反应。 具体来说，我会

Articular cartilage is a specialized, stiff yet flexible tissue lining bones within joints, such as the knee. This tissue is responsible for evenly distributing the enormous mechanical loads along the knee joint surfaces during physical activities. Knee cartilage is expected to manage these mechanical loads over many years of life without suffering damage. However, mechanical loads can clearly cause the breakdown of cartilage, as well as the bony structure underneath, leading to arthritis. Little research has explored the complexities of these mechanics in degrading or protecting articular cartilage and the underlying bone in the human knee. The purpose of this research program is to study the responses of articular cartilage and the underlying bone to short-term and long-term mechanical loads within the human knee. Specifically, I will