BIOMECHANICAL MODULATORS OF CARTILAGE AND BONE IN THE KNEE IN VIVO

关节软骨是关节内的一种特殊的、僵硬但灵活的组织衬里骨骼，如膝盖。在体育活动中，这种组织负责沿膝关节表面均匀分配巨大的机械载荷。膝关节软骨有望在多年的生命中承受这些机械负荷，而不会受到损害。然而，机械负荷显然会导致软骨及其下面的骨骼结构的破坏，从而导致关节炎。很少有研究探索这些机制在降解或保护人类膝盖的关节软骨和底层骨骼方面的复杂性。本研究的目的是研究人类膝关节内关节软骨和底层骨对短期和长期机械载荷的响应。具体来说，我会

Articular cartilage is a specialized, stiff yet flexible tissue lining bones within joints, such as the knee. This tissue is responsible for evenly distributing the enormous mechanical loads along the knee joint surfaces during physical activities. Knee cartilage is expected to manage these mechanical loads over many years of life without suffering damage. However, mechanical loads can clearly cause the breakdown of cartilage, as well as the bony structure underneath, leading to arthritis. Little research has explored the complexities of these mechanics in degrading or protecting articular cartilage and the underlying bone in the human knee. The purpose of this research program is to study the responses of articular cartilage and the underlying bone to short-term and long-term mechanical loads within the human knee. Specifically, I will