Environmental Agents as Modulators of Disease Processes

环境因素作为疾病过程的调节剂

• 批准号: 10852393
• 负责人: B Paige Lawrence
• 金额: $ 12.81万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10852393
• 关键词: Acceleration; Address; Affect; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease patient; American; Area; Attenuated; Award; Bioenergetics; Biological Assay; Biological Models; Brain; Caenorhabditis elegans; Chemical Exposure; Clinical; Communities; Community Health Education; Core Facility; Data; Deferoxamine; Development; Disease; Educational workshop; Electron Transport; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollutants; Environmental Risk Factor; Epidemiology; Exhibits; Faculty; Failure; Fostering; Foundations; Future; Generations; Genetic; Goals; Health; Homeostasis; Human; Incidence; Inductively Coupled Plasma Mass Spectrometry; Institution; International; Intervention; Ions; Iron; Iron Chelation; Iron Overload; Iron-Regulatory Proteins; Knowledge; Learning; Longevity; Mediating; Mediator; Medical; Mentors; Metals; Methods; Mission; Mitochondria; Modeling; Modernization; Molecular; Movement; Movement Disorders; National Institute of Environmental Health Sciences; Nature; Neurons; Neurophysiology - biologic function; Neurosciences; Outcome; Outcome Measure; Output; Oxidative Phosphorylation; Oxidative Stress; Paralysed; Parents; Pathogenesis; Pathway interactions; Positioning Attribute; Prevention; Process; Production; Professional Organizations; Proteins; Public Health; Regulation; Research; Research Personnel; Resources; Risk; Role; SLC11A2 gene; Science; Scientist; Signal Pathway; Stress; Stress Response Signaling; Swimming; Talents; Testing; Tissues; Translating; Visualization; age related; age related neurodegeneration; biological adaptation to stress; body system; career development; collaborative environment; combat; community engagement; community partnership; divalent metal; environmental agent; genetic approach; healthspan; improved; in vivo; innovation; insight; inter-institutional; knowledge base; member; mitochondrial dysfunction; mutant; nervous system disorder; neurotoxicity; neurotoxicology; neurotransmitter biosynthesis; next generation; novel; pharmacologic; prevent; programs; risk mitigation; selenoenzyme; sensor; skills; success; supportive environment; synergism; tool; uptake

Abstract of Parent Award The overarching goals of the Rochester Environmental Health Sciences Center (EHSC) are to prevent disease and improve health by advancing innovative and impactful translational environmental health research, engaging communities to address environmental health issues, and enhancing career development of talented environmental health investigators. More specifically, the goals of the Center are to: (1) enrich the ability to hypothesize and implement cutting-edge translational environmental health research using modern approaches that also move knowledge into action; (2) advance science by stimulating the prediction and prevention of detrimental exposures on health across the lifespan by developing and using the best available tools and approaches, and integrating new information to understand cumulative risks; (3) promote career development of the next generation of environmental health investigators in a diverse, inclusive, supportive, and collaborative environment; (4) foster interactions of Center members and community partners to cultivate new ideas and respond to issues of concern at the local, national, and international level; and (5) support existing and build new institutional and inter-institutional partnerships. The Rochester EHSC achieves these goals by providing a framework that is anchored in our overall mission to improve public health through the generation of fundamental knowledge and elaboration of mechanisms by which chemical exposures, alone or through interaction with other modifying factors, contribute to cumulative health risk across the life span. A key strength of the Center is that activities are not siloed within the study of a specific organ system or a single disease. As such, the central theme that integrates EHSC research and community engagement programs is the desire to understand how exposures and interactions of environmental factors affect health and disease across the lifespan. This theme weaves together and synergizes Center member efforts, such that the totality of our impact is greater than each part would achieve on its own. Further supporting the Center is a strong tradition of emphasizing and integrating basic mechanistic research in model systems with clinical and epidemiological approaches, which catalyzes multidirectional transformation of new information into actions. The Center also sustains strong community partnerships that develop, advise, and also learn from new methods and engage diverse communities in our region and across the nation. Unique and expanded strengths of our Center combined with emerging new areas underlie proposed Center activities, programs, and use of resources, and provide the foundation for future success. Further supporting our success is the broad- based scientific diversity of our faculty, which ideally positions us to apply integrative and innovative strategies to address critical questions in environmental health sciences.

家长奖摘要 罗切斯特环境健康科学中心（EHSC）的首要目标是预防疾病和改善 通过推进创新和有影响力的转化环境健康研究，让社区参与解决 环境卫生问题，并加强有才华的环境卫生调查人员的职业发展。更 具体而言，该中心的目标是：（1）丰富假设和实施尖端翻译的能力 环境健康研究采用现代方法，也将知识转化为行动;（2）通过以下方式推动科学发展： 通过开发和使用，促进预测和预防在整个生命周期中对健康有害的暴露 最佳可用工具和方法，并整合新信息以了解累积风险;（3）促进职业生涯 发展下一代的环境健康调查员在一个多元化，包容性，支持， （4）促进中心成员和社区合作伙伴的互动，以培养新的想法， 应对地方、国家和国际层面关注的问题;（5）支持现有的机构和建立新的机构 和机构间伙伴关系。罗切斯特EHSC通过提供一个锚定的框架来实现这些目标 我们的总体使命是通过创造基本知识和制定 化学品接触单独或通过与其他改变因素的相互作用， 整个生命周期的累积健康风险。该中心的一个关键优势是，活动不是孤立的研究， 特定器官系统或单一疾病。因此，整合EHSC研究和社区的中心主题 参与计划是希望了解环境因素的暴露和相互作用如何影响健康， 疾病在整个生命周期。这一主题交织在一起，协同中心成员的努力，使我们的整体 其影响大于每个部分单独实现的影响。进一步支持该中心是一个强大的传统，强调 并将模型系统中的基本机制研究与临床和流行病学方法相结合， 将新信息多方向转化为行动。该中心还维持着强大的社区伙伴关系 该组织开发、建议和学习新方法，并参与我们地区和全国各地的不同社区。 我们中心的独特和扩大的优势与新兴的新领域相结合，成为拟议的中心活动的基础， 计划和资源的使用，并为未来的成功奠定基础。支持我们成功的是广泛的- 基于我们教师的科学多样性，这使我们能够应用综合和创新策略来解决 环境健康科学中的关键问题。