Environmental Agents as Modulators of Disease Processes

家长奖摘要 罗彻斯特环境健康科学中心(EHSC)的首要目标是预防疾病和改善 通过推进创新和有影响力的翻译性环境健康研究，让社区参与解决 环境健康问题，以及加强有才华的环境健康调查人员的职业发展。更多 具体地说，该中心的目标是：(1)丰富假设和实施尖端翻译的能力 使用现代方法进行环境健康研究，将知识转化为行动；(2)通过 通过开发和使用来促进对健康有害暴露的预测和预防 最好的可用工具和方法，并整合新信息以了解累积风险；(3)促进职业生涯 发展新一代环境健康调查人员，以多样化、包容性、支持性和 协作环境；(4)促进中心成员和社区合作伙伴的互动，以培养新的想法和 应对地方、国家和国际各级关切的问题；以及(5)支持现有机构和建立新的机构 和机构间伙伴关系。Rochester EHSC通过提供一个固定的框架来实现这些目标 我们的总体使命是通过产生基本知识和阐述 化学暴露单独或通过与其他修饰因素相互作用促进的机制 一生中累积的健康风险。该中心的一个关键优势是，活动不是孤立于 特定的器官系统或单一的疾病。因此，整合EHSC研究和社区的中心主题 参与计划是希望了解环境因素的暴露和相互作用如何影响健康和 一生中都有疾病。这一主题交织在一起，并协同中心成员的努力，使我们的整体 影响比每个部分单独实现的效果都要大。进一步支持该中心是强调 将模型系统中的基础机制研究与临床和流行病学方法相结合，这将催化 多方位地将新信息转化为行动。该中心还维持着强大的社区合作伙伴关系 开发、建议和学习新的方法，并让我们地区和全国各地的不同社区参与进来。 我们中心独特和扩展的优势与新兴的新领域相结合，构成了拟议的中心活动的基础， 计划和资源的使用，并为未来的成功奠定基础。进一步支持我们成功的是广泛的- 以科学为基础的教师多样性，这使我们能够应用整合和创新的战略来解决 环境健康科学中的关键问题。

Abstract of Parent Award The overarching goals of the Rochester Environmental Health Sciences Center (EHSC) are to prevent disease and improve health by advancing innovative and impactful translational environmental health research, engaging communities to address environmental health issues, and enhancing career development of talented environmental health investigators. More specifically, the goals of the Center are to: (1) enrich the ability to hypothesize and implement cutting-edge translational environmental health research using modern approaches that also move knowledge into action; (2) advance science by stimulating the prediction and prevention of detrimental exposures on health across the lifespan by developing and using the best available tools and approaches, and integrating new information to understand cumulative risks; (3) promote career development of the next generation of environmental health investigators in a diverse, inclusive, supportive, and collaborative environment; (4) foster interactions of Center members and community partners to cultivate new ideas and respond to issues of concern at the local, national, and international level; and (5) support existing and build new institutional and inter-institutional partnerships. The Rochester EHSC achieves these goals by providing a framework that is anchored in our overall mission to improve public health through the generation of fundamental knowledge and elaboration of mechanisms by which chemical exposures, alone or through interaction with other modifying factors, contribute to cumulative health risk across the life span. A key strength of the Center is that activities are not siloed within the study of a specific organ system or a single disease. As such, the central theme that integrates EHSC research and community engagement programs is the desire to understand how exposures and interactions of environmental factors affect health and disease across the lifespan. This theme weaves together and synergizes Center member efforts, such that the totality of our impact is greater than each part would achieve on its own. Further supporting the Center is a strong tradition of emphasizing and integrating basic mechanistic research in model systems with clinical and epidemiological approaches, which catalyzes multidirectional transformation of new information into actions. The Center also sustains strong community partnerships that develop, advise, and also learn from new methods and engage diverse communities in our region and across the nation. Unique and expanded strengths of our Center combined with emerging new areas underlie proposed Center activities, programs, and use of resources, and provide the foundation for future success. Further supporting our success is the broad- based scientific diversity of our faculty, which ideally positions us to apply integrative and innovative strategies to address critical questions in environmental health sciences.