The study of recycling endosomes in innate immune cells

先天免疫细胞回收内体的研究

• 批准号: 356227-2013
• 负责人: Lacy, Paige
• 金额: $ 2.19万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528042
• 关键词: study; recycling; endosomes; innate; immune

Immune cells produce factors that have a profound effect on their surroundings. There are many types of immune cells that are important in regulating the immune system's response to outside triggers, such as bacteria and viruses. There are special factors that have a particularly important role in immunity, known as cytokines. Our studies are focused on the mechanisms that regulate the release of cytokines from immune cells. We have exciting new findings showing that immune cells secrete cytokines through a specialized mechanism, through recycling endosomes, that can be analyzed using cutting edge molecular biology and cell imaging techniques. The proposed study will reveal the precise molecular mechanisms that govern the release of potent regulatory cytokines. Students and trainees will have the opportunity to acquire new skills in molecular biology and microscopy to delve into the inner workings of immune cells and how they elaborate cytokines.

免疫细胞产生的因子对其周围环境有深远的影响。有许多类型的免疫细胞在调节免疫系统对外界刺激物（如细菌和病毒）的反应方面很重要。有一些特殊的因素在免疫中起着特别重要的作用，被称为细胞因子。我们的研究集中在调节免疫细胞释放细胞因子的机制上。我们有令人兴奋的新发现，表明免疫细胞通过一种特殊的机制分泌细胞因子，通过回收内体，可以使用尖端的分子生物学和细胞成像技术进行分析。本研究将揭示调控强效细胞因子释放的精确分子机制。学生和学员将有机会获得分子生物学和显微镜方面的新技能，深入研究免疫细胞的内部工作原理以及它们如何精心制作细胞因子。