Elucidating bacterial virulence by using an alternative host-pathogen model

使用替代宿主病原体模型阐明细菌毒力

• 批准号: 371421-2009
• 负责人: Charette, Steve
• 金额: $ 2.91万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528205
• 关键词: Elucidating; bacterial; virulence; using; alternative

Bacterial virulence is defined as the aptitude of a bacterial pathogen to trigger injury to a host organism, which are essential for the implementation and the multiplication of the pathogen in its host. The identification of virulence factors, i.e. molecules involved in bacterial virulence, and their functional description represent an important on-going effort to understand the behavior of bacterial pathogens. It is also a crucial element for the development of novel anti-bacterial drugs and vaccines.

细菌毒力被定义为细菌病原体触发对宿主生物体的损伤的能力，这对于病原体在其宿主中的实施和繁殖是必不可少的。鉴定毒力因子，即参与细菌毒力的分子，及其功能描述代表了理解细菌病原体行为的重要持续努力。它也是开发新型抗菌药物和疫苗的关键因素。