Regulation of neuropeptidergic cell homeostasis

神经肽能细胞稳态的调节

• 批准号: 386445-2010
• 负责人: Kurrasch, Deborah
• 金额: $ 2.33万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528882
• 关键词: Regulation; neuropeptidergic; cell; homeostasis

The hypothalamus is a region of the brain that is important for maintaining a variety of physiologies, such as body temperature, body weight, electrolyte balance, and sleep. We are interested in a type of neuron that is found in the hypothalamus, called a neurosecretory cell. Neurosecretory cells are the key organizing unit of the hypothalamus and are responsible for sending hormonal signals to other parts of the brain or to peripheral organs to regulate physiology. Upon activation, package neuropeptides that reside in the plasma membrane of primed neurosecretory cells are released into the blood. To ensure a rapid response, neurosecretory cells must quickly replenish packaged neuropeptides at the plasma membrane, allowing for the next round of rapid release. We know very little about how hormones are replenished in neurosecretory cells. In this proposal we will explore how neurosecretory cells regulated hormone levels. We will do this by determining which genes enable neurosecretory cells to sense intracellular hormone levels, and explore if other neurons in the hypothalamus use a similar signaling mechanism.

下丘脑是大脑的一个区域，对于维持各种生理状态（如体温、体重、电解质平衡和睡眠）非常重要。我们感兴趣的是在下丘脑中发现的一种神经元，称为神经分泌细胞。神经分泌细胞是下丘脑的关键组织单位，负责将激素信号发送到大脑的其他部分或外周器官以调节生理。激活后，位于启动的神经分泌细胞质膜中的包装神经肽被释放到血液中。为了确保快速反应，神经分泌细胞必须快速补充质膜上的包装神经肽，以便下一轮快速释放。我们对神经分泌细胞中激素是如何补充的知之甚少。在这个提议中，我们将探讨神经分泌细胞如何调节激素水平。我们将通过确定哪些基因使神经分泌细胞能够感知细胞内激素水平来做到这一点，并探索下丘脑中的其他神经元是否使用类似的信号传导机制。