Hormone control of embryonic brain development

胚胎大脑发育的激素控制

• 批准号: RGPIN-2016-04073
• 负责人: Kurrasch, Deborah
• 金额: $ 2.4万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629327
• 关键词: Hormone; control; embryonic; brain; development

Overview. The hypothalamus is a small but powerful region of the brain that is responsible for the production of hormones that govern physiological functions such as thirst, sleep, mood, sex drive, and hunger. Despite considerable knowledge about hormonal targets and surges, little is known about the ontogeny of the neurons that produce them. We recently uncovered that hypothalamic progenitors respond to endogenous hormones (e.g., β-estradiol, E2) and hormone-mimicking chemicals (e.g., bisphenol A, BPA), suggesting that hormones might play an unappreciated neurotrophic role during embryonic brain development.

概述。下丘脑是大脑中一个很小但功能强大的区域，负责产生控制生理功能的激素，如口渴、睡眠、情绪、性欲和饥饿。尽管我们对激素的目标和激增有相当多的了解，但对产生它们的神经元的个体发生却知之甚少。我们最近发现下丘脑祖细胞对内源性激素（如β-雌二醇，E2）和激素模拟化学物质（如双酚A， BPA）有反应，这表明激素可能在胚胎大脑发育过程中起着未被认识到的神经营养作用。