Bacterial invasion and mitochondrial dysfunction

细菌入侵和线粒体功能障碍

• 批准号: 418080-2012
• 负责人: Girardin, Stephen
• 金额: $ 3.5万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=530994
• 关键词: Bacterial; invasion; mitochondrial; dysfunction

Mitochondria are the organelles where energetic molecules are produced in the cell. In addition to this critical function, numerous converging evidence demonstrate that mitochondria also play key roles in the defense against dangerous bacteria. Not surprisingly, many reports also demonstrated that such bacteria target the mitochondrion as part of their virulence strategy. This proposal explores new territories of this complex interplay between mitochondria and disease-causing bacteria.

线粒体是细胞中产生能量分子的细胞器。除了这一关键功能外，许多证据表明，线粒体在防御危险细菌方面也发挥着关键作用。毫不奇怪，许多报告也表明，这些细菌的目标是作为其毒力策略的一部分的细菌。该提案探索了线粒体和致病细菌之间复杂相互作用的新领域。