Dissecting erythrocyte invasion mechanisms by the malaria parasite Plasmodium falciparum.

剖析疟疾寄生虫恶性疟原虫的红细胞入侵机制。

• 批准号: 418192-2012
• 负责人: Richard, Dave
• 金额: $ 2.26万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=531031
• 关键词: Dissecting; erythrocyte; invasion; mechanisms; malaria

The malaria parasite is the most important member of the Apicomplexa, a large and highly successful group of intracellular parasites. Invasion of host cells allows apicomplexan parasites access to a rich source of nutrients in a niche that is largely protected from host defenses. In contrast to many other pathogenic organisms, Plasmodium spp. can efficiently infect their hosts by rapidly gaining entry to cells using their own invasion apparatus to identify, penetrate, and establish themselves. All Apicomplexa adopt this common mode of host-cell entry but individual species incorporate unique features and utilize a specific set of ligand-receptor interactions.

疟疾寄生虫是顶复合体中最重要的成员，顶复合体是一个庞大而高度成功的细胞内寄生虫群。寄主细胞的入侵使顶复合体寄生虫能够在很大程度上免受寄主防御的生态位中获得丰富的营养来源。与许多其他致病性生物不同，疟原虫可以通过自身的入侵装置快速进入细胞，识别、穿透并建立自身，从而有效地感染宿主。所有顶复合体都采用这种共同的宿主细胞进入模式，但个别物种具有独特的特征，并利用一套特定的配体-受体相互作用。