Identification and characterization of novel RSK substrates

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The Ras-dependent extracellular signal-regulated kinase (ERK) cascade responds to a wide array of extracellular stimuli to regulate diverse biological functions, including cell proliferation, differentiation, migration and survival. This pathway plays particularly important roles during embryogenesis, where ERK signalling regulates various developmental processes downstream of growth factors, including gastrulation, neural patterning, limb development and placentation. Proper regulation of this signalling pathway is thus crucial during embryogenesis and adulthood, as activating/inactivating mutations within this cascade lead to various developmental disorders and diseases.