Identification and characterization of novel RSK substrates

新型 RSK 底物的鉴定和表征

• 批准号: 418400-2012
• 负责人: Roux, Philippe
• 金额: $ 2.04万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=551395
• 关键词: Identification; characterization; novel; RSK; substrates

The Ras-dependent extracellular signal-regulated kinase (ERK) cascade responds to a wide array of extracellular stimuli to regulate diverse biological functions, including cell proliferation, differentiation, migration and survival. This pathway plays particularly important roles during embryogenesis, where ERK signalling regulates various developmental processes downstream of growth factors, including gastrulation, neural patterning, limb development and placentation. Proper regulation of this signalling pathway is thus crucial during embryogenesis and adulthood, as activating/inactivating mutations within this cascade lead to various developmental disorders and diseases.

Ras依赖性细胞外信号调节激酶（ERK）级联反应响应于广泛的细胞外刺激以调节多种生物学功能，包括细胞增殖、分化、迁移和存活。该途径在胚胎发生过程中起着特别重要的作用，其中ERK信号传导调节生长因子下游的各种发育过程，包括原肠胚形成、神经模式形成、肢体发育和胎盘形成。因此，在胚胎发育和成年期，这种信号通路的适当调节是至关重要的，因为这种级联中的激活/失活突变会导致各种发育障碍和疾病。