Identification and characterization of novel RSK substrates

ras依赖的细胞外信号调节激酶（ERK）级联反应广泛的细胞外刺激，以调节多种生物功能，包括细胞增殖、分化、迁移和存活。这条通路在胚胎发生过程中起着特别重要的作用，其中ERK信号调节生长因子下游的各种发育过程，包括原肠胚形成、神经模式、肢体发育和胎盘。因此，对这一信号通路的适当调控在胚胎发生和成年期间至关重要，因为这一级联中的激活/灭活突变会导致各种发育障碍和疾病。

The Ras-dependent extracellular signal-regulated kinase (ERK) cascade responds to a wide array of extracellular stimuli to regulate diverse biological functions, including cell proliferation, differentiation, migration and survival. This pathway plays particularly important roles during embryogenesis, where ERK signalling regulates various developmental processes downstream of growth factors, including gastrulation, neural patterning, limb development and placentation. Proper regulation of this signalling pathway is thus crucial during embryogenesis and adulthood, as activating/inactivating mutations within this cascade lead to various developmental disorders and diseases.