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Probing MBL function in oligomannose-specific anti-HIV antibody responses

Probing MBL function in oligomannose-specific anti-HIV antibody responses
探讨 MBL 在寡甘露糖特异性抗 HIV 抗体反应中的功能
批准号:
276787
负责人:
Pantophlet Ralph A
金额:
$7.16万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-11-01 至 2013-11-01

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中文摘要
翻译
这项拨款申请的目的是探索一种重要的先天血清蛋白与HIV-1刺突蛋白组分之间的相互作用。我们的目标是评估这种相互作用是否会阻止某些免疫细胞检测到糖分子
英文摘要
The purpose of this grant application is to probe interactions between an important innate serum protein and components of the HIV-1 spike protein. Our goal is to assess whether this interaction prevents certain immune cells to detect sugar molecules that
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会议论文
A bacterially derived mimetic of mammalian oligomannose for eliciting anti-HIV glycan antibodies
Probing biased recognition of flu hemagglutinin by precursors of broadly neutralizing antibodies to the HA stem
Exploring immunogen requirements for the priming of hetero-subtypic neutralizing antibodies to flu
Sugar-coated designer immunogens to elicit HIV-1 neutralizing antibodies
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