Assembly and Dynamics of the DNA Replication Machine

DNA 复制机的组装和动力学

• 批准号: 435521-2013
• 负责人: ReyesLamothe, Rodrigo
• 金额: $ 3.5万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=533222
• 关键词: Assembly; Dynamics; DNA; Replication; Machine

Cells in our body carry the same genetic information as that of the embryo we once were. Coded in DNA, the information is reliably transferred from mother to daughter cells thousands of times as we grow. Molecular machines work inside the cells to copy and maintain this genetic information. The study of these machines, and others working in different cellular processes, has been hindered by a major limitation of biochemistry: the impossibility of reconstructing intracellular conditions in test tubes.

我们体内的细胞携带着与我们曾经的胚胎相同的遗传信息。在DNA中编码，随着我们的成长，信息可靠地从母体细胞转移到子细胞数千次。分子机器在细胞内工作，复制和维持这些遗传信息。对这些机器以及其他在不同细胞过程中工作的机器的研究一直受到生物化学的一个主要限制的阻碍：在试管中重建细胞内条件是不可能的。