Chromosome Biology

染色体生物学

• 批准号: CRC-2017-00263
• 负责人: ReyesLamothe, Rodrigo
• 金额: $ 7.29万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=692664
• 关键词: Chromosome; Biology

My lab aims to understand the activity of molecular machines as they work in the cell. Our research addresses the fact that the intracellular environment is too complex to be accurately reproduced in test tubes. Therefore, we develop and use advanced fluorescence microscopy techniques to quantify cellular activities in genetically tractable simple organisms. The focus of my team is the study of the machine that duplicates our genome, which is both our most active guardian against genetic mutations and the most frequent source of genomic instability. Our work contributes to the understanding of life and provides knowledge to prevent disease.

我的实验室旨在了解分子机器在细胞中工作时的活动。我们的研究解决了这样一个事实，即细胞内环境太复杂，无法在试管中准确复制。因此，我们开发并使用先进的荧光显微镜技术来量化遗传上易驯化的简单生物体中的细胞活动。我的团队的重点是对复制我们基因组的机器的研究，这既是我们抵御基因突变最活跃的守护者，也是基因组不稳定的最常见来源。我们的工作有助于理解生命，并提供预防疾病的知识。