IL-17RA and IL-17RC signaling in hematopoietic and non-hematopoietic cells

造血细胞和非造血细胞中的 IL-17RA 和 IL-17RC 信号传导

• 批准号: 436167-2013
• 负责人: Wang, Jun
• 金额: $ 2.19万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=533452
• 关键词: IL; 17RA; 17RC; signaling; hematopoietic

Cell death is one aspect of biological responses that mammalian cells respond to environmental stimuli. A wide range of pathogenic microorganism can cause cell death. There are two major types of cell death, apoptosis and necrosis. Upon infection, the cells go on different cell death pathways when they receive different signals, and the utilization of different way of dying and the rate of cell death will have a great impact on the outcome of infection. Proinflammatory cytokine signals are a major type of signals that mammalian cells receive through corresponding cytokine receptors during infection. Interleukin 17 (IL-17) is one of them. This research program will examine how the signals transmitted by IL-17 receptor (IL-17R) control the cell death program in two different types of cells, non-hematopoietic tissue structure cells and hematopoietic immune cells, upon infection with an intracellular bacterium called Chlamydia trachomatis. We have good reasons to believe that two subunits (IL-17RA and IL-17RC) of IL-17R may have different roles in regulating this fundamental biological process.

细胞死亡是哺乳动物细胞对环境刺激作出反应的生物反应的一方面。多种病原微生物均可引起细胞死亡。细胞死亡有两种主要类型：细胞凋亡和坏死。感染后，细胞在接受不同的信号时会走上不同的细胞死亡途径，不同死亡方式的利用和细胞死亡的速度会对感染的结果产生很大的影响。促炎细胞因子信号是哺乳动物细胞在感染期间通过相应细胞因子受体接收的主要信号类型。白介素 17 (IL-17) 就是其中之一。 该研究计划将研究在被称为沙眼衣原体的细胞内细菌感染后，IL-17 受体 (IL-17R) 传递的信号如何控制两种不同类型的细胞（非造血组织结构细胞和造血免疫细胞）的细胞死亡程序。我们有充分的理由相信 IL-17R 的两个亚基（IL-17RA 和 IL-17RC）可能在调节这一基本生物过程中发挥不同的作用。