Regulatory B cell development

调节性 B 细胞发育

• 批准号: RGPIN-2015-04544
• 负责人: Wang, Jun
• 金额: $ 2.19万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589865
• 关键词: Regulatory; cell; development

Regulatory B lymphocytes (Bregs) are a novel subset of B cells emerging as an important part of immune regulatory system, but are not well understood. While we do know that Bregs can inhibit immune responses through the production of immune suppressive cytokine IL-10, not all IL-10-producing B cells are functionally immune suppressive. Additionally, no specific marker currently exists to identify Bregs. My laboratory has obtained evidence that many B cells can produce IL-10 when they are activated, but only one subset of IL-10-producing cells is able to differentiate into Bregs, while others become immune activators or antibody producers. The objective of this research program is to understand the biology of Bregs, particularly the signaling pathways underlying their differentiation and function. The long term goal of this program is to establish a theory that can explain why and how IL-10-producing B cells develop into functionally different cells. We will carefully examine the function and signaling pathways in different subsets of B cells using molecular biology, cell biology and animal models. The knowledge attained from this research program will significantly advance our basic understanding about the signaling pathways in controlling the fate differentiation and functional development of novel regulatory B cells.

调节性B淋巴细胞（Regulatory B lymphocytes，BCLs）是近年来发现的一种新的免疫调节细胞亚群。虽然我们确实知道BcB细胞可以通过产生免疫抑制细胞因子IL-10来抑制免疫应答，但并非所有产生IL-10的B细胞都具有免疫抑制功能。此外，目前还没有特异性标记来识别BAE。我的实验室已经获得了证据，许多B细胞在被激活时可以产生IL-10，但只有一个产生IL-10的细胞亚群能够分化为BCLs，而其他细胞则成为免疫激活剂或抗体生产者。该研究计划的目的是了解BERMONIA的生物学，特别是其分化和功能的信号通路。这个项目的长期目标是建立一个理论，解释为什么以及如何产生IL-10的B细胞发育成功能不同的细胞。我们将使用分子生物学、细胞生物学和动物模型仔细研究B细胞不同亚群的功能和信号通路。从这个研究项目中获得的知识将显着推进我们对信号通路在控制新的调节性B细胞的命运分化和功能发育的基本理解。