Activation of parvalbumin-expressing inhibitory interneurons of the dorsal horn of the spinal cord alleviates mechanical hypersensitivity in a mouse model of neuropathic pain.

脊髓背角表达小白蛋白的抑制性中间神经元的激活可减轻神经性疼痛小鼠模型的机械过敏。

• 批准号: 281432
• 负责人: Sharif Behrang
• 金额: $ 1.27万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-02-01 至 2014-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=281432&lang=en
• 关键词: Behaviour Experiment; Disinhibition; Dorsal Horn; Immunohistochemistry; Pain; Parvalbumin; Saporin; Spinal Cord; Transgenic Mice; Viral Vectors

Chronic neuropathic pain (NeP) is a debilitating disease that follows nerve injury and persists long after the initial injury has subsided. Despite the plethora of medications and treatment modalities, NeP remains a disease with unmet medical needs that s

慢性神经病理性疼痛(NEP)是一种神经损伤后的衰弱疾病，在最初的损伤消退后持续很长时间。尽管有过多的药物和治疗方式，NEP仍然是一种医疗需求未得到满足的疾病，S