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Macrophage lipotoxic inflammation: Its mechanism, impact on insulin delivery and interplay with muscle

Macrophage lipotoxic inflammation: Its mechanism, impact on insulin delivery and interplay with muscle
巨噬细胞脂毒性炎症:其机制、对胰岛素输送的影响以及与肌肉的相互作用
批准号:
282097
负责人:
Klip Amira
金额:
$56.13万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-03-01 至 2018-03-01

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中文摘要
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英文摘要
Six million Canadian are obese and 2 million have type 2 diabetes. The obesity-diabetes epidemic is dismal to health budgets and quality of life. Insulin is an important hormone that controls the use of sugar by body tissues. A key feature of obesity is
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Cell biology and physiology of muscle insulin delivery, insulin action and insulin resistance leading to diabetes
Molecular convergence of insulin and muscle contraction signalling at Rab proteins: Implications for type 2 diabetes
CANADA RESEARCH CHAIRHOLDER - TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA
  • 批准号:
    241527
  • 项目类别:
  • 资助金额:
    $101.99万
  • 财政年份:
    2010
  • 负责人:
    Klip Amira
  • 依托单位:
Regulation of muscle glucose transporters by Rac and Rabs during insulin action and lipotoxicity