Macrophage lipotoxic inflammation: Its mechanism, impact on insulin delivery and interplay with muscle

巨噬细胞脂毒性炎症：其机制、对胰岛素输送的影响以及与肌肉的相互作用

• 批准号: 282097
• 负责人: Klip Amira
• 金额: $ 56.13万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-03-01 至 2018-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=282097&lang=en
• 关键词: Cell-Cell Communication; Insulin Transcytosis; Lipotoxicity; Macrophage Activation; Microvascular Endothelium; Muscle Insulin Resistance; Obesity-Induced Inflammation; Vesicular Traffic

Six million Canadian are obese and 2 million have type 2 diabetes. The obesity-diabetes epidemic is dismal to health budgets and quality of life. Insulin is an important hormone that controls the use of sugar by body tissues. A key feature of obesity is

600万加拿大人肥胖，200万人患有2型糖尿病。肥胖糖尿病的流行对健康预算和生活质量都是令人沮丧的。胰岛素是一种重要的激素，控制身体组织对糖的使用。 肥胖的一个关键特征是