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Regulation of muscle glucose transporters by Rac and Rabs during insulin action and lipotoxicity

Regulation of muscle glucose transporters by Rac and Rabs during insulin action and lipotoxicity
Rac 和 Rabs 在胰岛素作用和脂毒性过程中对肌肉葡萄糖转运蛋白的调节
批准号:
198711
负责人:
Klip Amira
金额:
$52.76万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2010
资助国家:
加拿大
项目状态:
已结题
起止时间:
2010-03-01 至 2015-03-01

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中文摘要
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英文摘要
Type 2 diabetes is alarmingly on the rise, urging us to investigate its molecular underpinnings. Sugars from our meals go to the blood and then are stored in our muscles, entering through glucose transporters called GLUT4. This process is triggered by ins
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Cell biology and physiology of muscle insulin delivery, insulin action and insulin resistance leading to diabetes
Macrophage lipotoxic inflammation: Its mechanism, impact on insulin delivery and interplay with muscle
Molecular convergence of insulin and muscle contraction signalling at Rab proteins: Implications for type 2 diabetes
CANADA RESEARCH CHAIRHOLDER - TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA
  • 批准号:
    241527
  • 项目类别:
  • 资助金额:
    $101.99万
  • 财政年份:
    2010
  • 负责人:
    Klip Amira
  • 依托单位:
国内基金
海外基金
棉铃虫葡萄糖转运蛋白(Glucose transporters)的分子鉴定
  • 批准号:
    31601644
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    20.0万元
  • 批准年份:
    2016
  • 负责人:
    袁一杨
  • 依托单位: