Topical susceptibility to TGF-beta: a new concept and key mechanism in myofibroblast generation

TGF-β的局部敏感性：肌成纤维细胞生成的新概念和关键机制

• 批准号: 279726
• 负责人: Kapus Andras
• 金额: $ 48.84万
• 依托单位: Unity Health Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-03-01 至 2018-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=279726&lang=en
• 关键词: Cytoskeleton; Epithelial-Mesenchymal Transtion; Mrtf; Myofibroblast; Primary Cilium; Promoter Studies; Tgfbeta Signaling; Time-Lapse Confocal Microscopy; Transcription Factors

Organ fibrosis is a chronic scarring process due to cycles of tissue injury and failed repair. It is estimated that 45% of all deaths in the western world can be attributed to some form of chronic fibrotic disease, which can develop as a consequence of c

器官纤维化是由于组织损伤和修复失败的循环而导致的慢性疤痕过程。 据估计，西方世界 45% 的死亡可归因于某种形式的慢性纤维化疾病，这种疾病可能是由于慢性纤维化引起的。