Preclinical models of natural killer cell-based immunotherapy to cure refractory childhood acute lymphoblastic leukemia

基于自然杀伤细胞的免疫疗法治疗难治性儿童急性淋巴细胞白血病的临床前模型

基本信息

项目摘要

Forty to fifty percent of children whose leukemia reappears following treatment die of their disease, underscoring an urgent need to improve current therapies. The only hope of a cure for these children is intensive highly toxic chemotherapy followed by t
治疗后白血病复发的儿童中有40%到50%死于疾病,这表明迫切需要改进目前的治疗方法。治愈这些孩子的唯一希望是高强度的高毒性化疗,然后是t

项目成果

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Duval Michel其他文献

Duval Michel的其他文献

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{{ truncateString('Duval Michel', 18)}}的其他基金

Phase I first-in-human trial for ThINKK adoptive immunotherapy in children with high-risk cancers
针对高危癌症儿童的ThINKK过继免疫疗法的I期首次人体试验
  • 批准号:
    484371
  • 财政年份:
    2023
  • 资助金额:
    $ 24.18万
  • 项目类别:
    Operating Grants
Phase I first-in-human trial of ThINKK adoptive immunotherapy in children with high-risk cancers
针对高危癌症儿童的ThINKK过继免疫疗法的I期首次人体试验
  • 批准号:
    473376
  • 财政年份:
    2022
  • 资助金额:
    $ 24.18万
  • 项目类别:
    Operating Grants
Adoptive transfers of in vitro differentiated plasmacytoid dendritic cells to prevent acute lymphoblastic leukemia relapse: mechanisms and biomarkers of sensitivity
体外分化浆细胞样树突状细胞的过继转移预防急性淋巴细胞白血病复发:机制和敏感性生物标志物
  • 批准号:
    402466
  • 财政年份:
    2019
  • 资助金额:
    $ 24.18万
  • 项目类别:
    Operating Grants
Toward the cure of neuroblastoma: innovative immunotherapeutic approaches
治愈神经母细胞瘤:创新的免疫治疗方法
  • 批准号:
    322744
  • 财政年份:
    2015
  • 资助金额:
    $ 24.18万
  • 项目类别:
    Operating Grants

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预测脐带血移植临床结果的生物标志物的验证
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通过临床数据分析建立改善脐带血移植结果的国际标准算法
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    2018
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Molecular basis for KIR ligand-mismatched cord blood transplantation for advanced neuroblastoma
KIR配体错配脐带血移植治疗晚期神经母细胞瘤的分子基础
  • 批准号:
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脐带血移植后巨核细胞生成的新途径
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脐带血移植与脑瘫康复联合治疗
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  • 财政年份:
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Comprehensive verification on life-saving mechanism of lethal dose radiation exposed individual by mixed umbilical cord blood transplantation
混合脐带血移植致死剂量辐射暴露个体救生机制的综合验证
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供体淋巴细胞输注治疗脐带血移植后疾病复发
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    2013
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建立有效的混合脐带血移植治疗致死剂量辐射暴露
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    25461868
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非血缘脐带血移植后免疫重建分析
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    24890220
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