Analysis of immune reconstitution after unrelated cord blood transplantation

非血缘脐带血移植后免疫重建分析

• 批准号: 24890220
• 负责人: KANDA Junya
• 金额: $ 1.91万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-08-31 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24890220/
• 关键词: 臍帯血移植; 遺伝子再構成; 免疫再構築

We analyzed the T-cell receptor beta-chain gene rearrangement by using high-throughput sequencing in patients who received unrelated cord blood or bone marrow transplantation. Immune reconstitution represented by T-cell repertoire diversity at 1 year after cord blood transplantation was comparable to that observed at 1 year after unrelated bone marrow transplantation. The frequency of each T cell clone dynamically changed after cord blood transplantation. We also suggested that the complementarity-determining region 3 sequence of T-cell receptor beta-chain of viral-specific T cells may be shared between patients.

我们使用高通量测序技术分析了接受无关脐带血或骨髓移植患者的T细胞受体β链基因重排。免疫重建代表T细胞库多样性在脐带血移植后1年的观察无关骨髓移植后1年。脐带血移植后每个T细胞克隆的频率动态变化。我们还提出，病毒特异性T细胞的T细胞受体β链的互补决定区3序列可能在患者之间共享。

项目成果

Effect of HLA mismatch on acute graft-versus-host disease

• DOI: 10.1007/s12185-013-1405-x
• 发表时间: 2013-09-01
• 期刊: INTERNATIONAL JOURNAL OF HEMATOLOGY
• 影响因子: 2.1
• 作者: Kanda, Junya

The impact of HLA-mismatch direction on the outcome of unrelated bone marrow transplantation: A retrospective analysis from the JSHCT HLA working group

HLA方向不匹配对无关骨髓移植结果的影响：JSHCT HLA工作组的回顾性分析

• 发表时间: 2014
• 作者: Kanda J;Maeda Y;Ohashi K;Fukuda T;Miyamura K;Mori S;Morishima Y,Atsuta Y;Kanda Y
• 通讯作者: Kanda Y

Universal cytotoxic activity of a HTLV-1 Tax-specific T cell clone from an HLA-A*24 : 02+ patient with adult T-cell leukemia against a variety of HTLV-I-infected T-cells

来自患有成人 T 细胞白血病的 HLA-A*24 : 02 患者的 HTLV-1 Tax 特异性 T 细胞克隆针对多种 HTLV-I 感染的 T 细胞的通用细胞毒活性

• DOI: 10.1016/j.imlet.2013.12.016
• 发表时间: 2014
• 期刊: Immunology Letters
• 影响因子: 4.4
• 作者: Yukie Tanaka;Rie Yamazaki;Kiriko Terasako-Saito;Hideki Nakasone;Yu Akahoshi;Hiroshi Nakano;Tomotaka Ugai;Hidenori Wada;Ryoko Yamasaki;Yuko Ishihara;Koji Kawamura;Kana Sakamoto;Masahiro Ashizawa;Miki Sato;Shun-ichi Kimura;Misato Kikuchi;Shi
• 通讯作者: Shi

Changes in the Clinical Impact of High-Risk Human Leukocyte Antigen Allele Mismatch Combinations on the Outcome of Unrelated Bone Marrow Transplantation

• DOI: 10.1016/j.bbmt.2014.01.003
• 发表时间: 2014-04-01
• 期刊: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
• 影响因子: 4.3
• 作者: Kanda, Yoshinobu;Kanda, Junya;Mori, Shinichiro
• 通讯作者: Mori, Shinichiro

Graft-versus-host disease and survival after cord blood transplantation for acute leukemia: a comparison of Japanese versus White populations.

移植物抗宿主病和脐带血移植治疗急性白血病后的存活率：日本人和白人的比较。

• DOI: 10.1016/j.bbmt.2014.01.020
• 发表时间: 2014-05
• 期刊: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
• 影响因子: 4.3
• 作者: Kuwatsuka, Yachiyo;Atsuta, Yoshiko;Horowitz, Mary M.;Inagaki, Jiro;Kanda, Junya;Kato, Koji;Koh, Katsuyoshi;Zhang, Mei-Jie;Eapen, Mary
• 通讯作者: Eapen, Mary