Development of Differential Mobility Spectrometry (DMS) technology for applications in phosphoproteomics.
Development of Differential Mobility Spectrometry (DMS) technology for applications in phosphoproteomics.
批准号:
460760-2013
负责人:
Wilson, Derek
金额:
$1.68万
依托单位:
依托单位国家:
加拿大
项目类别:
Engage Grants Program
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-01-01 至 2014-12-31
中文摘要
差示迁移率光谱(DMS)是一种功能强大的电离后过滤技术,可用于复杂样品的高选择性预过滤。ABSciex为他们的仪器引入了一种DMS技术,名为“SELEXion”。虽然所有离子迁移率技术都可以根据分析物的大小/形状和电荷提供一定程度的分离,但SELEXion还有一个额外的优势,即对目标物种的化学性质也非常敏感。当面对成分大小相似但化学成分略有不同的复杂混合物时,这一点尤其有用,这一点在基于DMS的异构体分离中得到了广泛的证明。另一个
英文摘要
Differential Mobility Spectrometry (DMS) is a powerful post-ionization filtration technique for mass spectrometry (MS), acting as a highly selective pre-filter for complex samples. ABSciex has introduced a DMS-technology for their instruments called 'SELEXion'. While all ion mobility techniques can provide a degree of separation based on analyte size/shape and charge, SELEXion has the added advantage of also being highly sensitive to the chemical properties of the target species. This is particularly useful when faced with complex mixtures in which the constituents are similar in size, but have subtly different chemistry, something which has been extensively demonstrated in the context of DMS-based separation of isomers. Another
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Conformational Disorder in Protein Function and Pathogenesis
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批准号:RGPIN-2019-06696
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.11万
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财政年份:2022
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负责人:Wilson, Derek
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依托单位:
Conformational Disorder in Protein Function and Pathogenesis
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批准号:RGPIN-2019-06696
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.11万
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财政年份:2021
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负责人:Wilson, Derek
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依托单位:
Technology enhanced biopharmaceuticals development and manufacturing (TEnBioDev)
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批准号:538347-2018
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项目类别:Collaborative Research and Development Grants
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资助金额:$18.94万
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财政年份:2021
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负责人:Wilson, Derek
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依托单位:
Technology enhanced biopharmaceuticals development and manufacturing (TEnBioDev)
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批准号:538347-2018
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项目类别:Collaborative Research and Development Grants
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资助金额:$28.41万
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财政年份:2020
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负责人:Wilson, Derek
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依托单位:
Conformational Disorder in Protein Function and Pathogenesis
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批准号:RGPIN-2019-06696
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.11万
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财政年份:2020
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负责人:Wilson, Derek
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依托单位:
Conformational Disorder in Protein Function and Pathogenesis
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批准号:RGPIN-2019-06696
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.11万
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财政年份:2019
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负责人:Wilson, Derek
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依托单位:
Technology enhanced biopharmaceuticals development and manufacturing (TEnBioDev)
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批准号:538347-2018
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项目类别:Collaborative Research and Development Grants
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资助金额:$9.47万
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财政年份:2019
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负责人:Wilson, Derek
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依托单位:
Conformational Disorder in Protein Function and Pathogenic Aggregation
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批准号:RGPIN-2014-03860
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.93万
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财政年份:2018
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负责人:Wilson, Derek
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依托单位:
Technology-enhanced biopharmaceuticals discovery and manufacturing (TBioDM)
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批准号:485321-2015
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项目类别:Collaborative Research and Development Grants
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资助金额:$16.03万
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财政年份:2017
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负责人:Wilson, Derek
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依托单位:
Conformational Disorder in Protein Function and Pathogenic Aggregation
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批准号:RGPIN-2014-03860
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.93万
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财政年份:2017
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负责人:Wilson, Derek
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依托单位:
Technology-enhanced biopharmaceuticals discovery and manufacturing (TBioDM)
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批准号:485321-2015
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项目类别:Collaborative Research and Development Grants
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资助金额:$24.04万
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财政年份:2016
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负责人:Wilson, Derek
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依托单位:
Conformational Disorder in Protein Function and Pathogenic Aggregation
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批准号:RGPIN-2014-03860
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.93万
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财政年份:2016
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负责人:Wilson, Derek
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依托单位:
Development of a mass spectrometry-enabled assay for the identification of new cellular targets for antibody-drug conjugates that utilize a novel payload delivery mechanism
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批准号:491958-2015
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项目类别:Engage Grants Program
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资助金额:$1.82万
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财政年份:2015
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负责人:Wilson, Derek
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依托单位:
Conformational Disorder in Protein Function and Pathogenic Aggregation
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批准号:RGPIN-2014-03860
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.93万
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财政年份:2015
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负责人:Wilson, Derek
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依托单位:
Technology-enhanced biopharmaceuticals discovery and manufacturing (TBioDM)
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批准号:485321-2015
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项目类别:Collaborative Research and Development Grants
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资助金额:$8.01万
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财政年份:2015
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负责人:Wilson, Derek
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依托单位:
Conformational Disorder in Protein Function and Pathogenic Aggregation
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批准号:RGPIN-2014-03860
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.93万
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财政年份:2014
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负责人:Wilson, Derek
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依托单位:
Hybrid ion mobility/mass spectrometry-based detectors for unambiguous target compound identification in the field.
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批准号:449356-2013
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项目类别:Engage Grants Program
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资助金额:$1.75万
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财政年份:2013
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负责人:Wilson, Derek
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依托单位:
Development of novel electrospray coupled microfluidic devices: New tools for elucidating the role of transient intermediates in protein function
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批准号:341925-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
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财政年份:2013
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负责人:Wilson, Derek
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依托单位:
Development of novel electrospray coupled microfluidic devices: New tools for elucidating the role of transient intermediates in protein function
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批准号:341925-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
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财政年份:2012
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负责人:Wilson, Derek
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依托单位:
Development of novel electrospray coupled microfluidic devices: New tools for elucidating the role of transient intermediates in protein function
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批准号:341925-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
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财政年份:2011
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负责人:Wilson, Derek
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依托单位:
海外基金