Bioreactor systems design for bioprocess innovations

用于生物工艺创新的生物反应器系统设计

• 批准号: 1909-2010
• 负责人: MooYoung, Murray
• 金额: $ 2.53万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=544008
• 关键词: Bioreactor; systems; design; bioprocess; innovations

This project will investigate bioprocessing criteria which are important to the development of innovative bio-manufacturing applications. The overall objective is to elucidate and characterize the equipment and operational conditions of a novel pre-sterilized disposable-plastic "bag" design of bioreactors for production of pharmaceuticals and other biological products. At present, relatively little fundamental bioprocessing information is available for these bioreactor types, especially for a second-generation design (introduced within the past two years) which are of special interest in this project because its capability (via two-dimensional rocking-shaking motion intensification of a flat bag) of improved aeration-agitation conditions. The study would quantify the mixing and aeration criteria for a range of microbial fermentation applications, thereby extending current knowledge now limited to animal-cell culture systems. Relevant process engineering correlations between the systems and operational variables will be established based on relatively inexpensive physically-simulated fermentation cultures.

该项目将研究生物加工标准，这对创新生物制造应用的发展至关重要。总体目标是阐明和表征用于生产药物和其他生物制品的生物反应器的新型预灭菌一次性塑料“袋”设计的设备和操作条件。目前，这些生物反应器类型的基本生物加工信息相对较少，特别是对于第二代设计（在过去两年内推出），这些设计在该项目中特别感兴趣，因为它的能力（通过二维摇摆-摇动运动增强平袋）改善充气搅拌条件。该研究将量化一系列微生物发酵应用的混合和通气标准，从而扩展目前仅限于动物细胞培养系统的知识。将根据相对便宜的物理模拟发酵培养物建立系统和操作变量之间的相关工艺工程相关性。