Regulation of expression of poly (A) binding protein in mammalian cells

哺乳动物细胞中聚腺苷酸结合蛋白表达的调节

• 批准号: 3542-2011
• 负责人: Bag, Jnanankur
• 金额: $ 3.5万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=544125
• 关键词: Regulation; expression; poly; binding; protein

Control of mRNA translation and stability is important for the regulation of gene expression, and play crucial roles in a variety of cellular processes including normal cellular growth and cancer. A large number of factors are involved in the process of mRNA translation. Amongst the various translation initiation factors the poly (A) binding protein plays a crucial role in initiation of mRNA translation. The cytoplasmic poly (A) binding protein (PABP1) binding protein binds to the poly (A) tract of eukaryotic mRNA. PABP1 interacts with the 5 ' cap bound eIF4G and the poly (A) tract of mRNA simultaneously and stimulates mRNA translation. Furthermore, PABP1 is believed to protect mRNAs from degradation. Because of the important roles of PABP1 in almost all aspects of mRNA metabolism it is crucial that expression of this important polypeptide is tightly controlled at multiple levels

mRNA翻译和稳定性的控制对于基因表达的调节是重要的，并且在包括正常细胞生长和癌症在内的各种细胞过程中发挥关键作用。在mRNA翻译过程中涉及到许多因素。在各种翻译起始因子中，poly（A）结合蛋白在mRNA翻译的起始中起关键作用。胞质多聚腺苷酸结合蛋白（PABP 1）结合蛋白与真核mRNA的多聚腺苷酸束结合。 PABP 1与5 '帽结合的eIF4G和mRNA的poly（A）束同时相互作用并刺激mRNA翻译。 此外，PABP 1被认为可以保护mRNA免受降解。由于PABP 1在mRNA代谢的几乎所有方面都具有重要作用，因此在多个水平上严格控制这种重要多肽的表达是至关重要的