4E-BP, the eukaryotic translation initiation factor 4E -binding protein, negatively regulates synaptic strength at the Drosophila NMJ and in mouse sympathetic ganglia

4E-BP，真核翻译起始因子 4E 结合蛋白，负调节果蝇 NMJ 和小鼠交感神经节的突触强度

• 批准号: 288442
• 负责人: Saviuk Natasha
• 金额: $ 0.07万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-05-01 至 2013-08-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=288442&lang=en
• 关键词: Acetylcholine; Cap-Dependent Translation; Drosophila Neuromuscular Junction; Eif4e-Binding Protein (4e-Bp); Homeostatic Plasticity; Sympathetic Ganglion; Synaptic Strength; Target Of Rapamycin (Mtor)

Synaptic connections are continuously modified, a feature of synapses that is required for higher brain functions such as learning and memory. While synaptic structure and function continuously change, many signaling mechanisms work in concert to stabiliz

突触连接是不断修改的，这是突触的一个特征，是学习和记忆等高级大脑功能所必需的。在突触结构和功能不断变化的同时，许多信号机制协同工作以保持稳定