CAP DEPENDENT TRANSLATION INITIATION REGULATED BY MOLECULAR MIMIC OF EIF4G

EIF4G 分子模拟物调控的 CAP 依赖性翻译起始

• 批准号: 6205787
• 负责人: NILS SONENBERG
• 金额: --
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6205787
• 关键词: biological products; biomedical resource; building /facility design /renovation; enzymes; lipids; nucleic acids; proteins; spectrometry; synchrotrons

This project has successfully sought funding from the NSF Biological Instrumentation program for the completion of a state of the art, bending magnet, protein crystallography station on the X9A beamline of the National Synchrotron Light Source (NSLS) at Brookhaven National Laboratories. The plan includes the purchase of the beamline optical components (i.e., monochromator and mirror) as well as a CCD detector and associated automation and computing hardware for rapid and efficient data collection and reduction. This facility will provide the crystallographic communities at the Albert Einstein College of Medicine (AECOM), Rockefeller University (RU) and the Sloan-Kettering Institute (SKI) with 170 days of access per year to high flux, tunable synchrotron radiation, and will allow for rapid progress on existing projects, as well as the initiation and timely completion of new structural problems. In addition, this facility will provide 60 days of beam time to the protein crystallography community nationwide through the NSLS General User program, which requires that at least 25% of the total beam time be distributed through a peer reviewed process administered by NSLS.

该项目已成功获得NSF的资助。 生物仪器计划完成的状态， X9 A上的艺术、弯曲磁铁、蛋白质晶体学站 布鲁克海文国家同步加速器光源（NSLS）光束线 国家实验室。 该计划包括购买光束线 光学组件（即，单色器和反射镜）以及CCD 检测器以及相关的自动化和计算硬件， 以及有效的数据收集和还原。 该设施将 为阿尔伯特·爱因斯坦科学院的晶体学团体提供了 医学院（AECOM），洛克菲勒大学（RU）和 Sloan-Kettering Institute（SKI）每年有170天的时间可以访问 高通量，可调同步辐射，并将允许快速 现有项目的进展情况，以及 解决新的结构性问题。 此外，该设施 将为蛋白质晶体学提供60天的光束时间 通过NSLS通用用户计划， 要求至少分配总射束时间的25% 通过由国家标准和法律事务处管理的同行审查程序。