Pseudomonas Global Regulatory Networks in Biofilms

生物膜中的假单胞菌全球监管网络

基本信息

  • 批准号:
    203595-2013
  • 负责人:
  • 金额:
    $ 3.13万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2014
  • 资助国家:
    加拿大
  • 起止时间:
    2014-01-01 至 2015-12-31
  • 项目状态:
    已结题

项目摘要

Our view of bacteria growing in any environment is changing as we gain more information on how bacteria grow as microbial communities, called biofilms. Perhaps the most interesting aspect of microbial communities is that the bacteria can communicate and coordinate their responses such that they operate in a manner similar to simple multicellular organisms. Bacteria control these community behaviours using systems called global regulatory networks. These systems allow the bacterial population to sense, respond, communicate and coordinate their responses. We are interested in three global regulatory systems: the stringent response which allows cells to sense and respond to nutrient limitation; quorum sensing which allows bacteria to sense their neighbours, respond and coordinate the population; and the GacA/S two component system involved in biofilm formation and maintenance. The goal of this research is to understand how these three systems work together in a bacterial biofilm. To carry out this research we will use a bacterium called Pseudomonas aeruginosa, known for its ability to form biofilms and its role in biofilm infections. We will examine the genes induced and repressed by these systems and in particular look for genes that overlap in at least two of these systems. We will use mutants in the global regulatory systems to examine their effect on the other systems. For instance we will use mutants in the stringent response to examine their effects on quorum sensing and the GacA/S system. Finally, we will examine the role of each of the global regulatory systems in the antibiotic resistance and their overall role in bacterial stress responses. This research will give us a better understanding of how bacteria form bacterial communities and potentially lead to the development of targets for new antibacterial therapies.
随着我们获得更多关于细菌如何作为微生物群落(称为生物膜)生长的信息,我们对细菌在任何环境中生长的观点都在改变。也许微生物群落最有趣的方面是,细菌可以交流和协调它们的反应,使它们以类似于简单的多细胞生物体的方式运行。细菌使用被称为全球监管网络的系统来控制这些社区行为。这些系统使细菌群体能够感知、反应、交流和协调他们的反应。我们对三个全球调控系统感兴趣:允许细胞感知并响应营养限制的严格反应;允许细菌感知邻居、响应和协调种群的群体感应;以及参与生物膜形成和维护的GacA/S两组分系统。这项研究的目标是了解这三个系统如何在细菌生物膜中协同工作。为了进行这项研究,我们将使用一种名为铜绿假单胞菌的细菌,它以形成生物膜的能力和在生物膜感染中的作用而闻名。我们将检查这些系统诱导和抑制的基因,特别是寻找至少两个这些系统中重叠的基因。我们将使用全球监管体系中的突变来检查它们对其他体系的影响。例如,我们将在严格反应中使用突变体来检查它们对群体感应和GacA/S系统的影响。最后,我们将研究每个全球调控系统在抗生素耐药性中的作用以及它们在细菌应激反应中的总体作用。这项研究将使我们更好地了解细菌是如何形成细菌群落的,并有可能导致新的抗菌疗法靶点的开发。

项目成果

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Storey, Douglas其他文献

Poor Knowledge and Nonuse of Long-Acting/Permanent Methods of Contraceptives in Six Districts in Indonesia
  • DOI:
    10.1177/1010539517738277
  • 发表时间:
    2017-11-01
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    Titaley, Christiana R.;Ariawan, Iwan;Storey, Douglas
  • 通讯作者:
    Storey, Douglas

Storey, Douglas的其他文献

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{{ truncateString('Storey, Douglas', 18)}}的其他基金

Pseudomonas Global Regulatory Networks in Biofilms
生物膜中的假单胞菌全球监管网络
  • 批准号:
    203595-2013
  • 财政年份:
    2017
  • 资助金额:
    $ 3.13万
  • 项目类别:
    Discovery Grants Program - Individual
Pseudomonas Global Regulatory Networks in Biofilms
生物膜中的假单胞菌全球监管网络
  • 批准号:
    203595-2013
  • 财政年份:
    2015
  • 资助金额:
    $ 3.13万
  • 项目类别:
    Discovery Grants Program - Individual
A Superconducting Radio Frequency Beam Separator for the ARIEL Electron Linear Accelerator
用于ARIEL电子直线加速器的超导射频束分离器
  • 批准号:
    443693-2013
  • 财政年份:
    2015
  • 资助金额:
    $ 3.13万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
A Superconducting Radio Frequency Beam Separator for the ARIEL Electron Linear Accelerator
用于ARIEL电子直线加速器的超导射频束分离器
  • 批准号:
    443693-2013
  • 财政年份:
    2014
  • 资助金额:
    $ 3.13万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Pseudomonas Global Regulatory Networks in Biofilms
生物膜中的假单胞菌全球监管网络
  • 批准号:
    203595-2013
  • 财政年份:
    2013
  • 资助金额:
    $ 3.13万
  • 项目类别:
    Discovery Grants Program - Individual
A Superconducting Radio Frequency Beam Separator for the ARIEL Electron Linear Accelerator
用于ARIEL电子直线加速器的超导射频束分离器
  • 批准号:
    443693-2013
  • 财政年份:
    2013
  • 资助金额:
    $ 3.13万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Global regulatory systems in pseudomonas aeruginosa
铜绿假单胞菌的全球监管系统
  • 批准号:
    203595-2007
  • 财政年份:
    2012
  • 资助金额:
    $ 3.13万
  • 项目类别:
    Discovery Grants Program - Individual
Global regulatory systems in pseudomonas aeruginosa
铜绿假单胞菌的全球监管系统
  • 批准号:
    203595-2007
  • 财政年份:
    2011
  • 资助金额:
    $ 3.13万
  • 项目类别:
    Discovery Grants Program - Individual
Global regulatory systems in pseudomonas aeruginosa
铜绿假单胞菌的全球监管系统
  • 批准号:
    203595-2007
  • 财政年份:
    2010
  • 资助金额:
    $ 3.13万
  • 项目类别:
    Discovery Grants Program - Individual
Long baseline measurement of neutrino oscillations
中微子振荡的长基线测量
  • 批准号:
    374452-2009
  • 财政年份:
    2009
  • 资助金额:
    $ 3.13万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Master's

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