Characterization and Exploitation of the Catalytic-Independent Antiretroviral Activities of the HIV Restriction Factor APOBEC3

HIV 限制因子 APOBEC3 的催化独立抗逆转录病毒活性的表征和开发

• 批准号: 297394
• 负责人: Langlois Marc-Andre
• 金额: $ 25.63万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-09-01 至 2016-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=297394&lang=en
• 关键词: Apobec3; Hiv; Innate Immunity; Murine Leukemia Virus; Restriction Factors

APOBEC3 proteins are best known as factors that have a protective role against HIV infection, also called restriction factors. These proteins can directly introduce deleterious mutations in the DNA of HIV upon cell entry, rendering it incapable of later s

APOBEC3蛋白是最为人所知的对HIV感染具有保护作用的因子，也称为限制因子。这些蛋白质可以在HIV进入细胞后直接在DNA中引入有害突变，使其不能在以后的细胞中发生突变。