The maintenance of [Ca2+]c oscillations in pituitary gonadotrophs and its impact on secretion

在分泌激素的细胞中，钙水平的上升是细胞分泌激素的信号。为了维持分泌，钙必须通过某些途径进入细胞。没有这些钙进入通路，细胞就不能继续分泌激素。我们研究了维持激素分泌所需的钙进入途径的性质和组成部分。我们的研究结果将有助于了解细胞如何控制激素分泌。这些知识将有助于开发药物来控制激素分泌，以治疗与激素分泌过多或不足有关的疾病。

In cells that secrete hormone, a rise in the level of calcium is the signal for the cell to secrete hormone. In order to maintain secretion, calcium has to enter the cells by some pathways. Without these calcium entering pathways, cells cannot continue to secrete hormone. We investigate the nature and the components of the calcium entering pathway that is needed to maintain hormone secretion. The results from our study will help to understand how cells control hormone secretion. This knowledge will be useful in developing drugs to control hormone secretion in diseases related to excessive or deficiency in hormone secretion.