Mechanical Overload in Tendons Produces Characteristic Nanoscaled Damage to Collagen Fibrils which Activates Cellular Remodelling

肌腱的机械过载会对胶原纤维产生特征性的纳米级损伤，从而激活细胞重塑

• 批准号: 292233
• 负责人: Lee J. M
• 金额: $ 27.97万
• 依托单位: Dalhousie University (Nova Scotia)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-09-01 至 2017-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=292233&lang=en
• 关键词: Afm; Biomechanics; Collagen; Ir Spectroscopy; Macrophages; Materials Science; Mechanical Testing; Orthopaedics; Sem; Tendon

Using very high magnification electron microscopy, we have shown that mechanical overload of tendons produce a characteristic kinking of their supporting collagen fibrils. This is the first evidence that an overload injury like a tendon strain produces co

使用非常高的放大倍数的电子显微镜，我们已经表明，机械超载的肌腱产生一个特征性的扭结，其支持胶原纤维。这是第一个证据表明，一个超载损伤，如肌腱应变产生co