What Is Failure? Nanoscaled Biomechanics of Collagen Disruption In Tissues & Semi-Synthetic Fibres

什么是失败？

• 批准号: RGPIN-2015-04317
• 负责人: Lee, JMichael
• 金额: $ 1.82万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589724
• 关键词: What; Failure; Nanoscaled; Biomechanics; Collagen

Collagen’s evolutionary longevity is a tribute to the survival value of its complex, self-assembled structure. While both elasticity and overload damage have been studied extensively at the light microscope level in connective tissues, it is below that scale—really at the nanometer scale—where mechanical load is borne. It is there that collagen’s strength is achieved—and perhaps more important for survival, where its toughness is determined. For the last 10 years or so, I have been interested in two fundamental questions:

胶原蛋白的进化寿命归功于其复杂的自我组装结构的生存价值。虽然在光学显微镜水平上已经对结缔组织的弹性和过载损伤进行了广泛的研究，但它低于该尺度-真正的纳米尺度-承受机械载荷。正是在那里，胶原蛋白的强度得到了加强，也许对生存更重要，因为它的韧性决定了。在过去的10年里，我一直对两个基本问题感兴趣：