To understand aging dependent microglial degeneration: impacts on neuronal function

衰老是一个让任何人都能活得足够长的问题，并会导致特有的分子和细胞变化。许多细胞和组织经历与功能下降相关的衰老变化。然而，衰老过程和与年龄相关的变化背后的基本遗传、生化和生理机制仍未得到很大程度的研究。我们社会中老年人数量的大幅增加对当今的细胞生物学构成了严重的挑战。

Aging is a matter of staying alive long enough for anyone, and will result in characteristic molecular and cellular changes. Many cells and tissues undergo senescent changes associated with a decline in function. However, the basic genetic, biochemical and physiological mechanisms underlying the process of aging and age-related changes remain largely underexplored. Substantial increases in the number of old persons in our society pose a serious challenge for today's cell biology.