Model of microcirculation: effect of cell interactions on blood flow

微循环模型：细胞相互作用对血流的影响

• 批准号: 357112-2008
• 负责人: Fenech, Marianne
• 金额: $ 1.37万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=549958
• 关键词: Model; microcirculation; effect; cell; interactions

Microcirculation in the human body, which is composed of numerous vessels with diameters less than 50 micrometers, is the main exchange site between blood and tissues. Knowledge of microcirculation is essential to understanding numerous pathologies and testing therapeutic solutions. The behaviour of blood in microcirculation is very complex because it cannot be considered as a liquid, but rather as a collection of interacting particles. Red blood cell circulation and interaction in micro-vessels is of great interest. Moreover, red blood cells may adversely affect blood behaviour, and as a consequence, blood flow if they are too abundant, less deformable or if they tend to aggregate abnormally.

人体微循环是血液和组织之间的主要交换场所，由许多直径小于50微米的血管组成。微循环的知识是必要的，以了解许多病理和测试治疗方案。血液在微循环中的行为是非常复杂的，因为它不能被认为是液体，而是相互作用的粒子的集合。微血管中的红细胞循环和相互作用引起了人们极大的兴趣。此外，红细胞可能会对血液行为产生不利影响，因此，如果红细胞过多、不易变形或倾向于异常聚集，就会影响血液流动。