New peptidomimetic approaches to target protein-protein interactions

靶向蛋白质-蛋白质相互作用的新肽模拟方法

• 批准号: 371503-2010
• 负责人: Biron, Eric
• 金额: $ 2.33万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=550054
• 关键词: New; peptidomimetic; approaches; target; protein

The cellular functions of a vast majority of proteins are performed through physical interactions with other proteins. These protein-protein interactions (PPI) are essential for many cellular and biological processes. Therefore, the inhibition of these interactions with chemical compounds provides great potential for the discovery of novel therapeutic agents and the development of innovative molecular tools to improve our understanding of biochemical pathways. Most of these PPI happen inside the cells. As a result, the demand for molecules that are able to penetrate cells and selectively disrupt specific PPI is rapidly increasing.

绝大多数蛋白质的细胞功能是通过与其他蛋白质的物理相互作用来实现的。这些蛋白质-蛋白质相互作用（PPI）对于许多细胞和生物过程是必不可少的。因此，抑制这些与化合物的相互作用为发现新的治疗药物和开发创新的分子工具以提高我们对生化途径的理解提供了巨大的潜力。大多数PPI发生在细胞内。因此，对能够穿透细胞并选择性破坏特定PPI的分子的需求正在迅速增加。