Utilisation de bactériocines de synthèse pour prévenir les infections alimentaires et vétérinaires

即使在2019年，微生物食品污染也很频繁（加拿大在2019年1月至2月期间有12起微生物召回）。最近的罗马沙拉产品污染事件在加拿大成为头条新闻。这些都是非常昂贵的食品加工商召回这些产品，但也失去了收入，由于失去消费者对产品的信心。2008年枫叶爆发的李斯特菌仍然铭刻在加拿大消费者的脑海中。对于食品加工者来说，这类事件严重损害了他们的声誉。传统的化学防腐剂（盐、硝酸盐、亚硫酸盐等）已经不足以满足消费者的需求，相反，消费者希望将它们从饮食中去除，这使得对天然防腐剂的需求不断增长。这种对替代品的需求并不是食品加工商所独有的，而是影响到食物链中的所有参与者，从畜牧业者到消费者的盘子。因此，必须找到一种解决方案来降低这些微生物污染的发生率，同时满足消费者对天然产品的需求。所提出的解决方案是使用细菌素，即益生菌产生的小的天然抗菌蛋白，来控制环境中的病原体。这项技术使我们能够精确和高效地瞄准我们消费链中发现的病原体。此外，它们是天然的，并被加拿大卫生部确认为安全的。这项技术代表了一种真实的天然替代品，可以替代农场动物中的化学防腐剂和抗生素。

Even in 2019, microbiological food contamination is frequent (12 microbiological recalls between January andFebruary 2019 in Canada). Recent cases of contaminations of Roman salad products have made headlinesacross Canada. These are very expensive for food processors to recall these products, but also lost revenue dueto the loss of consumer confidence in the product. The Maple Leaf outbreak of Listeria in 2008 is still etched inthe minds of Canadian consumers. For the food processor, this type of incident seriously damages thereputation.Traditional chemical preservatives (salts, nitrates, sulphites and others) are insufficient and do not respond tothe consumer's demand, who, on the contrary, wants to remove them from his diet, which allows the demandfor natural preservatives to be in continual growth. This need for alternatives is not unique to food processors,but affects all players in the food chain, from the livestock farmer to the consumer's plate. A solution musttherefore be found to reduce the incidence of these microbiological contaminations, while meeting consumerdemand for natural products.The proposed solution is the use of bacteriocins, that is small, natural antimicrobial proteins produced byprobiotics, to control pathogens in their environment. This technology makes it possible to target precisely andwith high efficiency the pathogens found in our consumption chain. In addition, they are natural and recognizedas safe by Health Canada. This technology represents a real natural alternative to chemical preservatives andantibiotics in farm animals.