Structural and mechanistic studies of inverting glycosidases

转化糖苷酶的结构和机制研究

• 批准号: 385751-2010
• 负责人: Rose, David
• 金额: $ 3.35万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=550256
• 关键词: Structural; mechanistic; studies; inverting; glycosidases

Sugars are everywhere in nature. They coat the surface of living cells, provide nutrition and energy to organisms, and are primary components of wood and other organic species, among many other roles. Sugars and their polymers, carbohydrates or polysaccharides, have been the focus of applications in deriving fuel from organic sources, in processes such as paper production, and in medical applications such as diabetes and cancer. These processes generally depend on the ability to degrade polysaccharides into individual sugars efficiently. Sugar processing is carried out by enzymes called glycoside hydrolases (GH) or glycosidases, which break the bonds that hold sugars together in their polymer chains.

糖在自然界中无处不在。它们覆盖在活细胞的表面，为生物体提供营养和能量，是木材和其他有机物种的主要组成部分，还有许多其他作用。糖及其聚合物、碳水化合物或多糖一直是从有机来源获得燃料、造纸等过程以及糖尿病和癌症等医疗应用的重点。这些过程通常取决于有效地将多糖分解成单个糖的能力。糖的加工过程是由糖苷水解酶（GH）或糖苷酶进行的，这种酶会破坏将糖在聚合物链中结合在一起的键。