Telomere integrity and stability of the differentiated state

端粒完整性和分化状态的稳定性

• 批准号: 293207
• 负责人: Harrington Lea A
• 金额: $ 58.13万
• 依托单位: Universit de Montral
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-09-01 至 2018-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=293207&lang=en
• 关键词: Apoptosis; Cell Proliferation And Cancer; Differentiation; Dna Damage; Dna Replication; Genome Stability; Telomerase; Telomeres

Cells have evolved a complex system to maintain the integrity of chromosome ends or telomeres. In humans, telomeres contain thousands of repeats of a simple 6-base pair sequence. In many cell types, the enzyme telomerase adds new telomere repeats during t

细胞已经进化出一个复杂的系统来维持染色体末端或端粒的完整性。在人类中，端粒包含数千个简单的6碱基对序列的重复。在许多类型的细胞中，端粒酶在端粒形成过程中增加了新的端粒重复序列。