Investigating the Neuronal and Vascular Contributions to the Spontaneous BOLD fMRI Signal Fluctuations Underlying Functional Connectivity

研究神经元和血管对功能连接下自发 BOLD fMRI 信号波动的贡献

• 批准号: 418443-2012
• 负责人: Chen, JingJean
• 金额: $ 2.11万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=551417
• 关键词: Investigating; Neuronal; Vascular; Contributions; Spontaneous

Magnetic resonance imaging (MRI) is a powerful technology offering unprecedented opportunities for studying the brain. In particular, functional MRI (fMRI), largely based on changes in blood oxygenation (blood-oxygen level dependent (BOLD)), has enabled the measurement of correlates of brain activity, and has since found applications in a wide range of areas spanning medicine and forensics. Recently, it was found that spontaneous fluctuations in the BOLD fMRI signal could be used to measure the synchrony (or connectivity) between brain regions. This technique, termed functional connectivity (fcMRI), has shown tremendous potential for studying the brain in health and disease. However, although fcMRI is widely assumed to reflect neuronal processes, the actual mechanisms underlying the BOLD signal fluctuations remain incompletely understood, leaving great potential for misinterpretation of fcMRI measurements.

磁共振成像（MRI）是一种强大的技术，为研究大脑提供了前所未有的机会。特别是功能性磁共振成像（fMRI），主要基于血氧水平（BOLD）的变化，已经能够测量大脑活动的相关性，并且已经在医学和法医学的广泛领域中找到了应用。最近，人们发现BOLD功能磁共振成像信号的自发波动可以用来测量大脑区域之间的同步性（或连通性）。这项技术被称为功能连接（fcMRI），在研究健康和疾病的大脑方面显示出巨大的潜力。然而，虽然fcMRI被广泛认为反映神经元的过程，BOLD信号波动的实际机制仍然不完全清楚，留下很大的可能性fcMRI测量的误解。