Identification and in vivo characterization of pharmacological chaperones of the dopamine transporter

多巴胺转运蛋白药理学伴侣的鉴定和体内表征

• 批准号: 307748
• 负责人: Beerepoot Pieter
• 金额: $ 7.65万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-10-01 至 2016-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=307748&lang=en
• 关键词: Dopamine; Dopamine Reuptake Inhibitors; Glutamate; Membrane Proteins; Monoamine Transporters; Pharmacological Chaperones; Protein Folding; Schizophrenia; Surface Expression Assay; Transgenic Animal Models Of Mental Illness

Our lab has previously discovered that genetically increasing a protein important in dopamine regulation, the dopamine transporter (DAT), can reduce dopamine signalling. Increasing function of DAT may be useful as a new treatment for two serious medical c

我们的实验室先前已经发现，遗传增加多巴胺调节中重要的蛋白质，多巴胺转运蛋白（DAT），可以减少多巴胺信号传导。增加DAT的功能可能是治疗两种严重内科疾病的新方法。