Characterization of the acute morphological and functional response of microglia to decreased oxygen levels and study of the mechanisms underlying microglial dynamic motility.

小胶质细胞对氧水平降低的急性形态和功能反应的表征以及小胶质细胞动态运动机制的研究。

• 批准号: 300751
• 负责人: Bernier Louis-Philippe
• 金额: $ 9.83万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-11-01 至 2016-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=300751&lang=en
• 关键词: Actin-Dependent Filopodia; Acute Brain Slices; Anoxia; Brain Metabolism; Cellular Motility; Cyclic Amp; Microglia; Nitric Oxide; Real-Time Two-Photon Microscopy; Stroke

Stroke is the third leading cause of death in Canada and more than 300,000 Canadians currently live with the debilitating effects of a stroke. Characterized by a transient lack of oxygen to the brain, its detrimental effects on the brain cells last far lo

中风是加拿大第三大死亡原因，目前有超过30万加拿大人生活在中风的衰弱影响下。其特征是大脑短暂缺氧，对脑细胞的有害影响持续很长时间。